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KMID : 0351619780190010049
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Kyungpook Medical Journal
1978 Volume.19 No. 1 p.49 ~ p.56
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Induction of Hepatic Phosphoenolpyruvate Carboxykinase by Bile Duct Ligation in Rats
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Abstract
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The main purpose of this study is to observe he change of phcsphcenolpyruvate carbosyb_inasc activity after the ligation of bile dace in rats.
After the ligation of the common bile duct, the levels of serti~m alkaline phosphatase end bilirubin were significantly increased, where: s pl.osphoer,olpyrucate carbosykinas~~ ;vas not det?cted in file - serum obtained from the normal and the bile duct lig.~ted rats, The bile duct ligation in the rat produced in nn increase in hepatic l;hosph~-,enolpyruvate carboYykinasc c;ctivicy. ~~i ithin ´?4. ~-" ;and 72 hours after file bile duct ligatic~:. hepatic phosphoerolpyruvate carbosykinas~ was increased about 2, 3, and ~-fold, respectively, b~_it th~~ ircreas of the enzyme activity- was inhibited in eke rat by i,.~jection of actinomycin D one hour before and 12 hours after the ligation. [ncoporation rate of r;mino acid mixture-I´IC anci orotic acid-I´C into the liver hrotci^ and R~´A was also increased by the brae duct ligation anci inhibited by- actinonlycir D.
The above resllltS suggest thai tnti blip dect 11ga110n tnaV Calls::b Ule 1nduCt20i1 Of hCnat~C ph´1~-phoenolpyruvate CaI-bogyiilnaS.´ :ii:d :`i2 is Clue t0 il´ie lllCreaSes ~}l the d212yme SynthC~ld.
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